Cyclops Issues - Helix 4CM + PS-2A + KHE 4x4 switcher

Hey Folks! Just got a Cyclops to use with my PS-2A, KHE switcher, and a Helix in 4 cable method into the PS-2A, but am having a lot of issues with grounding. Ensuring I have isolating going into the KHE for amp input and one for into the preamp as well since I have to do that to prevent a loop anyway due to 4 cable method using a Pyle hum eliminator and it works good for that at least..

My issue arises once I introduce the Cyclops. No matter what I do I have ground loops of some sort. It makes my amps in the switcher sound like I have thrown a blanket over them, creating squealing as well if I dial too much treble/presence on the amps. The preamp is louder and harder to balance even with instrument level selected. The amps are hard to get to a louder volume without the preamp being ear splittingly loud in comparison but I cannot dial it lower either. The preamp is a line level signal so I have the Cyclops set accordingly for that if I am not mistaken. All gear is powered by the same Furman rack mount power (M-8x2)

If it helps I follow the KHE diagram for the Cyclops Markus has put on the site, near the bottom of the page.
Found here: KHE + Fryette

only difference is that I have a Helix in 4CM method running from the SEND into the input of the Cyclops, and the return and output heading to the PS-2A as they should. I do run the cyclops into a isolation box as stated earlier to effectively mitigate the input ground loops but that does little to nothing in my case. I have tried it in front to little change, and without the issue is leagues worse.

Hope I can remedy this as I would like to be able to use it but so far its better for my setup to not be using it at present. Any help into this would be greatly appreciated

If its important at all the amps are a Revv G50, and a SYN-20IR, and the Preamp in question is the Headfirst Alta P1.

Just coming back to this that I have remedied my issue!

4CM just seems to be simply not compatible in this configuration. I simply routed it as you would a typical pedalboard (guitar in Helix > Helix 1/4" out > CYCLOPS input). Path A is set for all in front of amp effects and such.

The PS-2A loop just going to the send and returns of loop one of the Helix. Setting path B as a dedicated FX chain for post effects/modulations. Solved my issue and while I can’t use 4 cable method its not a deal breaker for my use case.